S100β Interaction with Tau Is Promoted by Zinc and Inhibited by Hyperphosphorylation in Alzheimer's Disease
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چکیده
منابع مشابه
S100b Interaction with Tau Is Promoted by Zinc and Inhibited by Hyperphosphorylation in Alzheimer’s Disease
The zinc-binding protein S100b has been identified as an interacting partner with the microtubule-associated protein tau. Both proteins are individually affected in Alzheimer’s disease (AD). S100b, is overexpressed in the disease, whereas hyperphosphorylated tau constitutes the primary component of neurofibrillary tangles. In this study, we examine factors that modulate their binding and the po...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2001
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.21-07-02240.2001